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KMID : 0604519990250010107
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Journal of the Society of Cosmetic Scientists of Korea
1999 Volume.25 No. 1 p.107 ~ p.119
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Synthesis and Characterization of the Conjugate of Poly(ethylene glycol)with Human Epidermal Growth Factor(hEGF) and its Cell Proliferation Effect
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1김기호/1Ki Ho Kim
1정시화/2히라노다카시/3박수남/1See-Hwa Jeong/2Takashi Hirano/3Soo Nam Park
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Abstract
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3 Kinds of PEG-hEGF conjugate, PEG1-hEGF, PEG5-hEGF, PEG10-hEGF, were
synthesized. Major fractions containing 2 chains of PEG were separated by preparative
GPC. Molecular weight was estimated by GPC-MALLS, TOF-Mass and SDS-PAGE,
and the data were well corresponding to calculated one. The cell proliferation effect of
the conjugates was evaluated, indicating that the conjugate bound to longer chain PEG
exhibits lower activity. Selective modification of hEGF and activity preservation of
PEG-hEGF conjugate are undergoing.
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